Etobicoke is in the west end of the City of Toronto, and lies between the Humber River and Etobicoke Creek, and was once its own city. The Lake is always to the South, and the airport is to the north (or northwest).
Etobicoke has a number of major east-west roadways (from the north): Steeles, which is the city limit, Finch, Rexdale, Dixon, Eglinton, Dandas, Bloor. The Queensway, and Lakeshore Boulevard. Interestingly, Dundas and Bloor criss-cross at Kipling, with Dundas being to the north east of Kipling, and Bloor being to the north west of Kipling
The community also has major north-south roadways about every half mile, most of which have access from the 401 Highway to provide quick access to all neighbourhoods. These north-south roads are Royal York (which continues as Weston Rd north of the 401), Islington, Kipling, Martin Grove, , The east Mall (east of the 427) and The West Mall (west of the 427), and Hihgway 27 north of the 401
There are three major east-west highways, in order from the lakeshore: the Queen Elizabeth Way (QEW), the 401, and the 407 toll route (which basically runs along the boundary between Mississauga and Brampton, north of the 401).
Etobicoke's major north-south highway is the 427, connecting the QEW and lakeshore with the 401, the airport and the 407 by Woodbridge.
At the south end of Highway 427, it connects to the Queen Elizabeth Way (QEW) west to Oakville and Hamilton, which east of the 427 is the Gardiner Expressway which winds along Toronto's lakefront into the downtown core. Watch exit signs when driving through the 401-427 "Spaghetti Junction", to ensure you get to your proper destination.
The #401 Macdonald Cartier Freeway, connects Windsor, London, Kitchener, Toronto, Kingston, and Montreal. This 12 lane highway built in the early 1960s when the area was still half urban and rural. Contrary to popular mis-conception (likely because of its size and traffic), the 401 IS NOT the "trans-Canada Highway". The 401 has "express" lanes on the inside for those not needing access to the next few exits, and the "local" lanes at the outside for those planning to exit from the 401 within the next several exits. Every few exists is an interchange area for cars to switch between the local and express lanes.
Further east, near Jane Street, the 401 connects with Highway 400, the major roadway to Barrie and Ontario's cottage country, as well as to the /Transportation-Canada Highway at Sudbury and North Bay.
More about the highways